In case you’ve began to consider longevity or perimenopause and that’s taken you down a rabbit gap of dietary supplements, I really feel you. AgelessRX got here on my radar in 2024 after a deep dive on researching LDN. As a result of I used to be able to hold coaching, however my physique felt totally different and I wanted to determine tips on how to help it.
As a result of most runners I work with aren’t searching for shortcuts. They’re already doing the issues:
- coaching persistently
- dialing in diet
- prioritizing sleep (or at the very least attempting to)
And but… generally one thing nonetheless feels off.
Power dips. Restoration lags. That underlying “blah” feeling that’s laborious to elucidate, however very actual. I used to be discovering this not simply in myself, however in so a lot of our runners over 40 that I needed to discover choices. The complement market has an choice for every little thing, however once more I needed one thing with a bit extra proof behind it and I used to be open to being the guinea pig for the group.
I’m so glad I used to be.
What’s AgelessRX?
An especially essential distinction, AgelessRx isn’t a complement firm. It’s a telehealth platform.
Meaning every little thing is overseen by U.S.-licensed physicians, it’s HIPAA-compliant, they usually work with compounding pharmacy companions to supply remedies which are usually more durable to entry by way of a standard physician’s workplace.
The aim is admittedly about making longevity-focused care extra accessible and personalised.
In case you resolve to discover it, you’re not simply clicking “add to cart.” There’s a screening course of to find out if one thing is suitable for you, and ongoing check-ins to assist handle dosing alongside the way in which.
They provide a variety of choices—issues like NAD+, LDN, Metformin, GLP-1s, Sermorelin, Rapamycin, B12, and extra. I can’t converse to all of these, and I gained’t fake to. However I can share my expertise with LDN and NAD+, that are those I’ve frolicked researching and testing myself.
And the explanation I even went down this path comes again to what I’m seeing on daily basis as a coach.
At this level, over 60% of our one-on-one athletes are girls navigating perimenopause or menopause (and sure, loads of males over 40, too). Which suggests we’ve had a front-row seat to how shifting hormones can present up otherwise for everybody.
However there are undoubtedly patterns.
The most typical issues we hear?
Persistent, random aches.
Sleep disruptions.
And that underlying fatigue that doesn’t fairly match the trouble you’re placing in.
Which lead me to have a look at what can I do past sensible coaching to higher help my altering physique (and my athletes!).
How Does it Work
- On-line consumption type / medical questionnaire
- Doctor evaluations and approves (or declines) your prescription
- Remedy ships on to your door from a compounding pharmacy.
- I’ve had no points with pausing once I didn’t want and located it tremendous simple to cancel one subscription once I determined it wasn’t the suitable time for me.
- Be aware: some states require a video seek the advice of first
- ID verification required
- Subscription based mostly!! That is the one odd grievance from folks, however it’s clearly marked it auto renews and as famous I discovered it tremendous simple to show off all on my own with out calling or utilizing on-line help.
Low Dose Naltraxone for Aches, Cravings and Mind Fog
Low Dose Naltrexone (LDN) is a a lot smaller dose of a medicine initially utilized in larger doses for different medical circumstances.
At low doses (usually ~1–4.5 mg), it seems to work otherwise, primarily by:
- supporting the physique’s endorphin manufacturing
- modulating the immune system
- serving to scale back irritation
That is the place it will get fascinating for runners.
As a result of once we discuss feeling higher, working stronger, and recovering effectively… we’re actually speaking about these actual techniques.
After I entered perimenopause I went from being an athlete who hardly ever had accidents or greater than just a little twinge right here an there to somebody with random aches on a regular basis. I felt comfy beginning hormone substitute remedy and that made a distinction in assuaging the unexplained accidents, however there was nonetheless aches that made no sense.
I did a ton of analysis on LDN and felt like AgelessRX was a dependable place to check it out.
LDN continues to be an rising space of analysis, however there are some promising research, notably round irritation, ache, and immune response.
- A research on fibromyalgia discovered that LDN lowered ache and improved temper in contributors
- Analysis printed in Medical Rheumatology confirmed enhancements in signs for folks with Crohn’s illness and different inflammatory circumstances
- A evaluate in Frontiers in Immunology highlighted LDN’s potential position in regulating the immune system and decreasing continual irritation
Whereas these aren’t working particular research, they level to one thing related: when irritation and immune operate enhance, folks are likely to really feel higher general.
And if you really feel higher… you prepare higher.
What had been my outcomes?
Some I anticipated and a few I didn’t, however all had been sufficient that I quietly really useful it to shut buddies over the following 12 months and noticed a lot of them have massive adjustments too.
The factor to recollect is these aren’t on the spot in a single day magic outcomes. This isn’t a ache killer, however it’s one thing that for me made a big change in my general feeling.
- Lowered the continual irritation, so my random ankle ache or sudden neck ache stopped
- Lowered sugar cravings which was tremendous useful as we don’t course of sugar as effectively with perimenopause
- Improved sleep
- My temper additionally felt elevated
Buddies with autoimmune points discovered their physique felt higher and one other with ADHD even discovered it helped them with the mind fog. I’m not calling it a remedy all or a miracle drug. All of us are nonetheless working towards good sleep hygiene, hydrating, fueling and figuring out.
Nevertheless it felt prefer it was making these items simpler once more.
NAD+ for Power and Mind Fog
After I first began sharing about HRT, some of the fascinating responses I received was from girls who mentioned, “I’m not prepared for that but… however I attempted NAD+ and felt superb.”
Power. Temper. Psychological readability.
It saved arising time and again.
So like with LDN, I made a decision to remain open to a brand new thought and take a look at it myself.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in each cell in your physique, and it performs a central position in how we produce power on the mobile stage—particularly contained in the mitochondria, that are basically the engines driving every little thing out of your exercises to your restoration. Analysis reveals that NAD+ ranges decline as we age, and that drop is tied to adjustments in mitochondrial operate, metabolism, and general mobile well being.
That’s a giant a part of why it’s getting a lot consideration within the longevity house.
There’s additionally rising analysis taking a look at how supporting NAD+ ranges could affect growing older pathways, irritation, and muscle operate. For instance, a current paper in Biochemical and Biophysical Analysis Communications explores how NAD+ precursors might play a job in age-related ailments by supporting mobile restore processes and power metabolism.
And in additional utilized physiology, research have proven that restoring NAD+ ranges in growing older muscle can enhance mitochondrial operate, scale back oxidative stress, and even improve endurance and restoration in preclinical fashions.
So when folks say they “really feel higher,” there may be at the very least a physiological speculation behind it.
I attempted NAD+ as a nasal spray after listening to all these optimistic experiences. And for me? It was… tremendous.
Not dangerous, not life-changing. I didn’t discover a dramatic shift in power or restoration, and finally determined it wasn’t one thing I needed to maintain investing in long-term. The upside: it was simple to strive, and simply as simple to cease.
Ought to You Strive LDN or NAD+?
And I feel that final level is a very essential a part of this dialog.
As a result of whereas the science is promising, it’s nonetheless evolving. Loads of the strongest information just isn’t in runners navigating real-life coaching, stress, sleep, and hormones .
However that doesn’t imply it’s not value exploring.
It simply means we method it the identical method we method coaching: with curiosity, context, and a willingness to regulate.
For some, they is perhaps a significant lever for power and restoration. For others, it is perhaps impartial.
We’re on the cusp of a time the place instantly growing older, perimenopause and menopause are being studied, mentioned extra brazenly and considered with options. BUT we don’t have all of the solutions but and I can completely say that the expertise varies by individual.
So I’m simply hopeful that by sharing extra and speaking about it, I give others data I want I’d had on day certainly one of realizing one thing is totally different and never realizing tips on how to resolve it.
This isn’t a sponsored evaluate, however my expertise with LDN was so good that after a 12 months I reached out to AgelessRX.com as a result of I actually needed to share. They had been variety sufficient to supply a reduction code for 10% any first buy.
Ageless RX Low cost Code: RUNTOTHEFINISH
Personally I belief them and have preferred all of the communication and repair that not simply I’ve obtained, however what I’ve seen in buddies who’ve tried it.
